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Clinical trial population adjacent: Obese individuals with higher adiposity, MASLD, T2D/high HbA1c, and/or significant liver fat and metabolic panel improvement goals

Effectiveness As many as 20% to 50% of people dont respond to methotrexate, according to various studies, but there is no way to know beforehand who will benefit and who wont

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Small number of research groups : A limited number of research groups have conducted most studies, which may affect the generalizability of the results